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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name HMGB1 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Rattus norvegicus
Tissues/Cell_line retinas
Methods siRNA injection, qPCR, immunohistochemistry, TUNEL assay, Western blot
Expression pattern associated
Functional description HMGB1 siRNA can reduce retinal cell damage induced by high glucose in vitro and in vivo and delay DR progress through the HMGB1-IKKβ-NFκB signaling pathway.
PubMed ID 28352154
Year 2017
Title HMGB1 siRNA can reduce damage to retinal cells induced by high glucose in vitro and in vivo.
Drug-related ncRNA NO

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